I was actually doing a small vignette
on Coley's mixed toxins when I came across Bertram Buxton. Coley was in the habit
of treating sarcomas with a heat-killed mixture of two bacteria, Serratia marcescens
and Streptococcus pyogenes. He injected his brew into cancers of the colon
and uterus. "Coley's mixed toxins" as the brew was known, had mixed results,
but a few of them were spectacular.
Now before you shrink back in
horror and disgust, these were serious germs. Various strains and infections of
Streptococcus pyogenes can cause impetigo, strep throat, scarlet fever, erysipelas
and toxic shock syndrome. Serratia marcescens plays a role in some forms
of bacteraemia, so neither is something to take lightly, but the treatment was certainly
less deadly than the disease.
More importantly, medical lore
had recorded cases where gangrene infections had seen off cancers, so there was
a scientific basis of sorts. A decade or so back, researchers started to see that
the secret was probably a cytokine, a chemical known as Tumour Necrosis Factor or
TNF. For a while, there was a flurry of activity, but then it all died away again.
Anyhow, that took me to the pages
of Science to see what had been said about Coley's toxins. That brought me
to Dr Buxton when I encountered his obituary, written after he died in Devon at
the age of 82, in 1934.
Buxton had somehow fetched up
on a cholera ship in New York harbour in the 1890s. I will have to poke around later,
to find out what a cholera ship was, but I can make a guess. Ten years or so later,
now aged 50, he was working as a pathologist, "preparing Coley's toxins for the treatment
of inoperable sarcoma".
NOT Dr. Buxton. |
"His sole diversion was riding
the bicycle and his remarkable skill in trick performances was long remembered by
pedestrians on the upper west side of Central Park."
Back in England and now aged 60,
Buxton turned to plant physiology at the John Innes Horticultural Institution, and
"produced by mutation a giant fertile hybrid of foxglove which was recognised
by the Kew authorities as a new species".
Ewing quoted an earlier obituary
in The Times, which referred to his work in agglutination, laying the foundation
for studies in the assay of toxins and antitoxins. "The perfect charm, breadth
of view, and superb technique are memories of Buxton which will not easily be forgotten
by his many pupils and associates."
My current writing program has
no place for Buxton, so I thought I would share with you this man who seems to have
devoted his life to knowledge.
They just don't breed them like
that any more.
No, not the foxgloves, silly!
No, not the foxgloves, silly!
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